Make a beeline for Leonardo's damaged but still moving Last Supper in the church of Santa Maria delle Grazie Visit the Brera museum, home to masterpieces by Mantegna, Raphael, and Piero della Francesca Don't miss the exquisite Duomo in all its Gothic splendor Art and Culture Shopping Nightlife Overnight Stay in Milan

Take a boat ride down the spectacular Grand Canal Hang out in the gracefully spacious Piazza San Marco before visiting the Basilica, with its shimmering mosaics Bask in the Bellinis and other Venetian masterpieces at the marvelous Galleria dell'Accademia Art and Culture Architecture Shopping Overnight Stay in Venice

Take a boat ride down the spectacular Grand Canal Hang out in the gracefully spacious Piazza San Marco before visiting the Basilica, with its shimmering mosaics Bask in the Bellinis and other Venetian masterpieces at the marvelous Galleria dell'Accademia Art and Culture Architecture Shopping Overnight Stay in Venice

Tour the gargartuan Castello Estense, home to the ruling d'Este family; don't miss the dungeon Walk by the glittering Palazzo Diamante, and go in if there's a special exhibition running Check out the lively 15th-century frescoes by Cosmè Tura in the Salone dei Mesi at Palazzo Schifanoia Museums Architecture Art and Culture Overnight Stay in Ferrara

Make reservations in advance to visit the Uffizi, the world's greatest collection of Renaissance art Visit the Duomo, admire Brunelleschi's groundbreaking cupola, and climb to the top if you have the stamina Visit the Accademia and marvel at Michelangelo's David, his Slaves, and his St. Matthew Experience convent life while contemplating the tranquil paintings by Fra Angelico, housed in Museo di San Marco Art and Culture Museums Shopping Overnight Stay in Florence

Make reservations in advance to visit the Uffizi, the world's greatest collection of Renaissance art Visit the Duomo, admire Brunelleschi's groundbreaking cupola, and climb to the top if you have the stamina Visit the Accademia and marvel at Michelangelo's David, his Slaves, and his St. Matthew Experience convent life while contemplating the tranquil paintings by Fra Angelico, housed in Museo di San Marco Art and Culture Museums Shopping Overnight Stay in Florence

Make reservations in advance to visit the Uffizi, the world's greatest collection of Renaissance art Visit the Duomo, admire Brunelleschi's groundbreaking cupola, and climb to the top if you have the stamina Visit the Accademia and marvel at Michelangelo's David, his Slaves, and his St. Matthew Experience convent life while contemplating the tranquil paintings by Fra Angelico, housed in Museo di San Marco Art and Culture Museums Shopping Overnight Stay in Florence

Don't miss Piero della Francesca's inspiring fresco cycle of Legends of the True Cross in the Basilica di San Francesco in Arezzo Check out Arezzo's oddly-shaped Piazza Grande, and the 16th-century loggia designed by Giorgio Vasari Make sure to see two very moving works by Fra Angelico in the Museo Diocesano in lovely Cortona Art and Culture Natural Beauty Overnight Stay in Arezzo & Cortona

Before going inside to see Luca Signorelli's riveting Last Judgment fresco, admire the façade of the Duomo, with its delicately sculpted figures by Lorenzo Maitani See works that inspired the Renaissance with a visit to the Museo Archeologico Claudio Faina Experience underground Orvieto on a tour of the city's tunnels and caverns Art and Culture Architecture Overnight Stay in Orvieto

Queue with the masses to visit the Sistine Chapel and the rest of the massive Musei Vaticani Take a "Caravaggio tour" of churches with works by the temperamental master View stunning sculptures by Bernini, as well as works by Raphael, Coreggio, and Titian at the Villa Borghese Art and Culture Architecture Nightlife Overnight Stay in Rome

Queue with the masses to visit the Sistine Chapel and the rest of the massive Musei Vaticani Take a "Caravaggio tour" of churches with works by the temperamental master View stunning sculptures by Bernini, as well as works by Raphael, Coreggio, and Titian at the Villa Borghese Art and Culture Architecture Nightlife Overnight Stay in Rome